Our group has a longstanding interest in developing the synthetic methodology based on the versatile reactivity of nitro compounds and their derivatives. Our key advances in this area are related to the exploration of the synthetic value of nitrosoalkenes, fluorinated nitroalkenes and cyclic nitronates.

We are deeply interested in exploring the mechanisms of our reactions, using state-of-the-art techniques and equipment. The instrumental methods, such as in situ IR and UV-vis monitoring and electron paramagnetic resonance (EPR) spectroscopy, allow us to observe the course of the reaction in direct way. We also employ advanced computational methods in order to thoroughly investigate the reaction mechanisms.

We apply the developed methodology for concise total synthesis of medically relevant compounds. The synthesis is supported by computational chemistry methods, such as molecular docking and DFT.